FLG and atopic eczema: Many candidate gene studies in atopic eczema have been performed on relatively small case collections and have generated data that have not been replicated in further studies.17,18 However, in 1 of 5 reported microsatellite-based genome screens, the 1q21 locus was identified, and we have shown that a large component of this signal was a result of FLG null mutations.4