For example, immunotherapy of mice with preexisting cancer (including spontaneously derived B16 melanoma) treated with HSP preparations derived from syngeneic cancer resulted in a delay of progression of the primary cancer, a reduced metastatic load, and prolongation of life span, whereas treatment with HSP preparations derived from cancers other than the syngeneic cancer did not provide such protection [1,2]. Here, HSP90B2P is linked to cancer.