In studies aimed at elucidating determinants of tumor-suppressive properties of periostin, the periostin C-terminal region was found to be sufficient to suppress anchorage-independent growth in T24 bladder cancer cells [72], to suppress cell invasiveness in SBT31A bladder cancer cells, and to abrogate the metastatic potential of highly metastatic B16F10 mouse melanoma cells in an in vivo assay [42]. This evidence concerns the gene POSTN and urinary bladder cancer.