Association of NCX1 intronic 14 bp indel (rs11274804) with cardiovascular disease was studied in two Eastern European sample sets: essential hypertension (HYPEST, Estonia; n = 1122; cases n = 470/controls = 652) and coronary artery disease, CAD (CADCZ, Czech; n = 670; cases n = 257/controls = 413). This evidence concerns the gene SLC8A1 and coronary artery disorder.