We assessed the serum levels of cytokines (IL–1, IL–2,IL–4, IL–6, IL–8, IL–10, IFN–gamma, TNF–alpha, GM–CSF), chemokines (MCP–1 and MIP–1alpha)and growth factors (VEGF and bFGF) in laryngeal cancer patients before, during and after surgery. The gene discussed is FGF2; the disease is laryngeal carcinoma.