FLT1 and rheumatoid arthritis: In the dynamics of angiogenesis, the intervention of two tyrosinekinase receptors – VEGF-R1 and VEGF-R2 [13, 14] - has been identified as responsible for the growing signals transmitted to the endothelial cells [15]; more, VEGF-R1 blockade in animal models determined the abortion of the joint destruction process [16], confirming the supposition that VEGF/VEGF-R1 overexpression is a promoter of osteochondral destruction, starting from the early stages of rheumatoid arthritis [17].