Several materials andprocedures have been acquired or performed for the first time in our country, such as: the cultivation and manipulation of U87MG line (aninternational glioblastoma line brought for the first time in Bucharest), the breeding and manipulation of athymic –knock–out mice (NUDECrl: CD–1 Foxn1, acquired from Charles River laboratories), the stereotactic inoculation of glioblastoma cells and finally the developmentof glioblastoma in the brain of nude mice, proved by histopathological studies and immunohistochemistry images. This evidence concerns the gene FOXN1 and glioblastoma.