BBS2 and Bardet-Biedl syndrome: Particularly, the proteins associated with diseases that are phenotypically similar, such as BBS and ALMS, also localize to the centrosomal regions and within the basal bodies of ciliated cells, and studies of mouse models for BBS (Bbs1–/–, Bbs2–/–, Bbs4–/– and MKKS–/–) have implicated several BBS proteins in ciliary’s function and intracellular trafficking.