We found that B-LCLs expressing only TRIM5 alleles 1–5 efficiently restricted SIVsmE543 and HIV-1 infection, whereas B-LCLs expressing only TRIM5α molecule from the group of alleles 6–11 were more permissive for infection by these virus constructs (Fig. 3A, B). The gene discussed is TRIM5; the disease is HIV-1 infection.