The β1 integrins have also been reported to promote tumor cell migration in a matrigel [33].To make it more confusing, the role of the α5β1 in the process of 3D cell invasion,tumor growth and metastasis formation is controversially discussed because several reportsdescribed an invasion enhancing, tumor growth promoting, and metastasisincreasing role that is inversely correlated with E-cadherin expression [34, 35],but others reported it vice versa [36–38].The differences of the results might be explained by the use of different tumorcell lines. The gene discussed is CDH1; the disease is neoplasm.