Endothelial cellsexpressed L1-CAM and PECAM-1 have been described as counter-receptors thatinteract with cancer cell αvβ3 integrin [87, 88].Endothelial cellsexpressed L1-CAM, and P-selectin have been described as a ligands for CD24 [7, 89].A loss of E-cadherin cell-cell contacts is important for single cell invasionand has recently been discovered as a tumor suppressor gene [5]. The gene discussed is CDH1; the disease is neoplasm.