Compared to controls, dsNKX3-1-381 robustly induced NKX3-1 mRNA expression in both WES (∼3.5-fold, p<0.05) and COS1 (∼5.7-fold, p<0.01) cells (Fig. 2G), as well as displayed altered morphology and decreased cell density characteristic of the predicted tumor suppressor function of NKX3-1 [14] (Fig. S3). This evidence concerns the gene NKX3-1 and neoplasm.