SPP1 and neoplasm: Additional PEA3 family target genes implicated in neoplasia include; urokinase plasminogen activator (uPA), vimentin, cyclooxygenase-2 (COX-2), Twist, MUC4, WT1, osteopontin, mammaglobin, cyclin D3 and HER2 [31], [34], [51]–[60].