WNT1 and neoplasm: Specifically, the dominant-interfering mutant ΔNPEA3En suppressed early onset tumor formation in MMTV/Wnt1 mice (Figure 5A), and ΔNPEA3En expression was markedly suppressed in those tumors that did develop in bigenic MMTV/Wnt1, MMTV/ΔNPEA3En animals (Figure 6).