Furthermore, Pea3 activates transcription of multiple neoplasia-associated genes, including MMP genes, COX-2, Twist, osteopontin, uPA, vimentin, MUC4, WT1, mammaglobin, cyclin D3 and HER2[31], [34], [42], [48]–[60]. The gene discussed is TWIST1; the disease is neoplasm.