Our main findings were: i) although serum NSE levels were not different between AD patients and control elderly individuals, serum of S100B levels were significantly lower in DA patients; ii) there were a positive correlation between S100B levels and AD severity (evaluated by CDR and MMSE) as well as a negative correlation between NSE levels and the severity of morphological brain alterations, evaluated by MRI. Here, ENO2 is linked to Alzheimer disease.