IRAK4 and infection: As demonstrated here, the expression of IL-8/CXCL8, Gro-α/CXCL1, MCP-2/CCL8 and MIP-3α/CCL20 was compromised in LPS-stimulated IRAK4-deficient monocytes (Figure 3, Table 1), suggesting a diminished recruitment of neutrophils, monocytes, lymphocytes, basophils and eosinophils to sites of infection.