A possible role of hEag1 in leukemia cell proliferation could be shown by growth and migration inhibition of the hEag1-expressing cell lines PLB-985, K562, UT-7 and HEL and primary clinical samples by the potassium channel blockers astemizole, imipramine, the hEag1 specific monoclonal antibody mAb56 and siRNA knockdown [9]. This evidence concerns the gene KCNA3 and leukemia.