VIM and Age-related cataract: Therefore, we suggest that the expression of αB-crystallin is higher in senile cataract, which is consistent with two previously reported findings: 1) the reduced thermal stability and the dominant negative effects of mutant αB-crystallin may be the direct cause of cataract because αB-crystallin null mice have clear lenses [24]; and 2) the decrease of vimentin may be initiated by damage to the epithelial cells, leading to degradation of the cytoskeleton, and appears to be related to the formation of age-related cataract [27].