In patients with OGC, a number of primary and secondary causes of reduced dietary intake are at work simultaneously, including dysphagia (McKernan et al, 2008), early satiety (Davis et al, 2006), chronic nausea (McKernan et al, 2008), alterations in circulating neuroendocrine hormones (e.g., ghrelin (Isomoto et al, 2005) and leptin (Huang et al, 2005; Zhao et al, 2007)), hypogeusia/hyposmia (Plata-Salaman, 2000), and cytokine-induced central anorexia (Plata-Salaman, 2001; Turrin et al, 2004). This evidence concerns the gene LEP and Anorexia.