TP53 and cancer: Tumour p53 mutation was significantly associated with grade 3 cancer (P<0.0001, 2FET; OR=10.3(4.9,21.8); power=1.00); axillary lymph node metastasis (P=0.004, 2FET; OR=2.4(1.3,4.3); power=0.84); ER-negative tumours (P<0.0001, 2FET; OR=4.9(2.6,9.0); power=1.00); HER2 expression (P=0.003, 2FET; OR=3.3(1.5,7.0); power=0.85) and triple-negative tumours (P=0.001, 2FET; OR=3.3(1.7,6.5); power=0.92).