RP was reported in a few cases.20 The genetic basis of the disease is due to mutations in the WFS1 gene, which has been postulated to be an endoplasmic reticulum calcium channel transporter in pancreatic β-cells and neurons.18 Although diabetes and optic atrophy represent the minimal diagnostic criteria, other clinical characteristics include neurodegenerative disease involving the hypothalamus, brain stem, and the cerebellum. Here, WFS1 is linked to hereditary optic atrophy.