In general, NOS3 gene polymorphisms have been reported to act as ‘susceptibility genes’ in various cardiovascular and pulmonary diseases.7 GT substitution in exon 7 of codon 298,8 4a/b polymorphism in intron 4,9, 10 T-786C mutation in the 5'-flanking region,11, 12 and high numbers of CA repeat in intron 13 of the NOS3 gene are also associated with an excess risk for CAD.13 Among them, a common variant located in exon 7 (G984T) of the NOS3 gene that modifies its coding sequence (Glu298Asp) has been linked by several groups to the risk for CAD and acute myocardial infarction (MI). Here, NOS3 is linked to acute myocardial infarction.