NOS3 and coronary atherosclerosis: In an Australian population, Cai et al did not detect any association between NOS3 gene polymorphism and the risk of CAD.19 Hibi et al showed that patients who are homozygous for the Glu298Asp polymorphism might be genetically predisposed to acute MI; however, this mutation apparently is not related to the severity of coronary atherosclerosis.15 In contrast, Hingorani et al observed an excess of homozygotes for Asp298 variant among patients with CAD.