We found that the median CXCR4 and SDF1 mRNA levels were 109 compared to 3 and 117 compared to 2 in the tumors compared to normal tissue (Fig. 1A and 1B), and the expression of CXCR4 correlated with tumor grade (p < 0.001, ANOVA). This evidence concerns the gene CXCL12 and neoplasm.