Two other genes, Irf8 and Itga1 targeted by a RIS (Table 4) are also of interest: Irf8 is not included in the RTCGD database but is a known CIS [52] and the ITGA1 locus is repressed by methylation during megakaryopoiesis in humans [53]. This evidence concerns the gene ITGA1 and in situ carcinoma.