CD68 and Miyoshi myopathy: It has been suggested that CCS may be conclusively diagnosed using cytology, immunohistochemistry (HMB- 45+ and S-100+ stains), cytogenetic analysis (demonstrating the specific translocation), and electron microscopy (to supply ultrastructural evidence for the presence of melanosomes).[2, 8–10] However, CCS shares a similar immunohistochemical profile with MM, with two exceptions: (i) CD68 is more specific for MM and has not been reported positive in CCS, and (ii) CCS displays occasional positivity for chromogranin while MM does not [Table 1].[3, 11]