Removal of extracellular PGE2 is partially performed by a specific prostaglandin transporter, PGT, and further degradation of PGE2 is by the enzymes 15-prostaglandin-dehydrogenase, 15-PGDH, and carbonyl reductase, CBR, of which, both the activity by PGT and 15-PGDH are reduced in CRC cells, Figure 1[3,38,39]. Here, HPGD is linked to colorectal carcinoma.