We recently described a novel 21 kDa cell surface and cytoplasmic protein expressed by HL and ALCL cell lines, other CD30+ non-Hodgkin lymphoma cell lines, HRS cells in HL clinical biopsies, and the neoplastic cells in biopsies from ALCL and aggressive NHL patients[24]. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.