The networks related to cellular development and connective tissue disorder showed that enzymes such as phosphoglycerate 12 mutase (glycolysis), muscle proteins such as myosin heavy chain 4 (Actin cytoskeleton signaling), nebulin-related anchoring protein (Actin binding protein) were significantly down regulated by TWEAK (Figure 7). Here, TNFSF12 is linked to connective tissue disorder.