Larger clinical obesity studies of plasma endocannabinoid and NAE levels correlated with FAAH P129T genotype are needed in normal, mildly overweight and severely obese subjects to confirm the presence of linked plasma and FAAH gene ECS biomarkers for the risk of severe obesity since independent confirmation could, in turn, lead to more selective endocannabinoid or EC analogue treatment strategies. Here, FAAH is linked to Obesity.