IL6 and myotonic dystrophy type 2: Epidemiologists have consistently found that chronically elevated plasma levels of systemic markers and potential mediators of inflammation and the acute-phase response such as C-reactive protein, fibrinogen, interleukin 6, tumor necrosis factor-alpha (TNFα), and macrophage migration inhibitory factor (MIF) are associated with an increased risk of future IR [4], [49], suggesting that factors that either elicit or contribute to chronic inflammation may participate in the pathogenesis of IR and DM2.