Consequently, KRAS mutation analysis is a prerequisite for anti-EGFR therapy in metastasized CRC and only patients with tumors that harbor no KRAS mutations receive this therapy (European Medicine Agency – EMEA-H-C-741 and H-C-558 and U.S. Food and Drug Administration - FDA Application No. (BLA) 125084 and No. (BLA) 125147). This evidence concerns the gene EGFR and colorectal carcinoma.