CNR1 and myeloid sarcoma: Using animal models of MS like experimental autoimmune encephalomylelitis (EAE), CB1R and CB2R have been shown to be specific markers of MS plaque cell subtypes [21]; furthermore, CB1R has been proven to mediate suppression of CNS autoimmune inflammation on neurons, whilst CB2R had the same anti-inflammatory role on autoreactive T cells [22].