The results indicated that z-VAD-fmk (50 μM) or z-DEVD-fmk (50 μM) pretreatment had no effect on c-Jun and JNK activation induced by ABL-N (Figure 6f), further suggesting that caspases were downstream targets of JNK signaling in response to ABL-N in breast cancer cells. This evidence concerns the gene JUN and breast carcinoma.