EGFR and metastatic malignant neoplasm in the lymph nodes: Regarding EGFR overexpression, nine out of the 47 paired samples (19.2%) were discordant for EGFR status between the primary site and the metastases: only three patients who had 2+ or 3+ in the primary tumors and changed to 0 or 1+ in lymph node metastases, and another six patients who had 0 or 1+ in the primary tumors and changed to 2+ or 3+ in lymph node metastases.