In the scenario, where Neisseria gonorrhoeae is able to establish a chronic inflammation within the prostate by either insufficient immune response, repeated infections, or delay/lack of treatment, the local production of inflammatory cytokines (e.g. interleukin-6 and interleukin-8) and reactive oxygen species as well as recruitment of neutrophils and macrophages that carry inflammatory agents (e.g. myloperoxidase and nitric oxidase) may induce cell and genome damage leading to increased cell proliferation. The gene discussed is CXCL8; the disease is infection.