HMGB1 and Stroke: Serum HMGB1 strongly promotes inflammation, regulates dendritic cell function and migration, skews the T cell response towards a Th1 profile and induces proliferation and the release of IL-6 [11], [12], [13] Consequently, HMGB1, which has been shown to be elevated within 24 hours following stroke or myocardial infarction, could act as important player in the modulation of post stroke immune responses.