ALDH2 and cardiac hypertrophy: Meanwhile, facilitated clearance of acetaldehyde via mitochondrial aldehyde dehydrogenase (ALDH-2) was shown to be beneficial in alleviating acute and chronic ethanol exposure-induced contractile dysfunction and/or myocardial hypertrophy [9], [10], further supporting the detrimental role of acetaldehyde in alcohol-induced myocardial damage.