SERTAD1 and cancer: Fig. S1). Detailed histopathological analyses did not reveal abnormalities in Sei1-null tissues (data not shown). When wt, Sei1-het and Sei1-null cohorts of mice were aged, their survival curves were indistinguishable (Supp. Fig. S2), as well as the pathologies observed in moribund old mice (see below the incidence of spontaneous cancer).