However, other processes relevant to the regenerative response, such as steatosis, evaluated by the accumulation of Nile red positive droplets (Fig. 3C) and liver cholesterol and triglyceride content (Fig. 3D–E), appeared to be little affected by the lack of functional TRs, although there was a moderate but statistically significant increase (p<0.05) in liver cholesterol and triglycerides in TRα1/TRβ KO animals at 48 h. The gene discussed is THRB; the disease is steatosis.