Some candidate proteins with iron-sulfur centers include the MutY (4595) homologue (a glycosylase in base excision repair); the yeast protein, Rad3 (856918), which is essential for viability, and its human homologues XPD (2068) and Fancj (83990) (helicases involved in nucleotide excision repair and the Fanconi anemia repair pathway, respectively); and Pri2 (853821) (essential to RNA primer synthesis) [57]–[60]. This evidence concerns the gene BRIP1 and Fanconi anemia.