One of these was a post hoc analysis of the prevention of restenosis with tranilast and its outcomes (PRESTO) trial, involving analysis of data from 1997 patients with type 2 diabetes at baseline who received either metformin or other oral antidiabetic treatments that do not influence the action of insulin as their primary mechanism (i.e. patients receiving a thiazolidinedione were excluded) (61). Here, INS is linked to type 2 diabetes mellitus.