In the present study, to clarify the effects of UCP0045037 and DJ-1 on brain stroke and oxidative insult, we examined the effects of UCP0045037 on focal ischemia/reperfusion-induced oxidative brain damage in an in vivo neuronal model and on hydrogen peroxide (H2O2)-induced cell death in rat ventral mesencephalic neurons; or in normal and DJ-1-knockdown SH-SY5Y cells in an in vitro cultured neuronal model. Here, PARK7 is linked to ischemia.