Just over 44% of HCC patients with a Child–Pugh A score had a CD4 T-cell response (8 out of 18), whereas only 15% of HCC patients with a Child–Pugh B or C score had as CD4 T-cell response (2 out of 13), suggesting that an AFP-specific Th1 response is mainly detected in HCC patients with a Child–Pugh A score (Figure 5). Here, CD4 is linked to hepatocellular carcinoma.