In addition, in some cancer cells, TNF-α enhances cells migration and metastasis through NF-κB-dependent induction of the chemokine receptor CXCR4, monocyte chemoattractant protein-1 (MCP-1), IL-8 and intercellular adhesion molecule-1 (Kulbe et al, 2005). The gene discussed is NFKB1; the disease is cancer.