CLDN8 and colon adenocarcinoma: Seventeen of these 20 genes changed in a reverse manner in HT29 colon adenocarcinoma cells under NS398 COX2 inhibitor treatment, 14 of them (including upregulated somatostatin, claudin 8, peptide YY, and downregulated cadherin 3, KIAA1199) at a significance of P<0.05 (Figure 2A).