SPARC and neoplasm: Figure 2D indicates that SPARC expression in SPARC siRNA-transfected Daoy-SP cells was decreased compared with that in Daoy-SP cells and was comparable with that of Daoy-P parental controls. However, as shown in Figure 2A, siRNA against SPARC or anti-SPARC antibody could not restore Daoy-SP tumour cell-induced angiogenesis.