Studies show that overexpression of NRP1 promotes, while blockade of NRP1 inhibits, tumour cell survival and migration (Miao et al, 2000; Bachelder et al, 2001, 2003; Barr et al, 2005; Chabbert-de Ponnat et al, 2006), consistent with a pro-tumorigenic role of NRP1 and direct contribution to tumour progression. The gene discussed is NRP1; the disease is neoplasm.