Since NRP1 has been strongly implicated in the migratory response to VEGF in endothelial cells (Soker et al, 1998; Whitaker et al, 2001; Bernatchez et al, 2002; Lee et al, 2002), initially we examined the effects of EG3287 on tumour cell chemotaxis induced by VEGF. This evidence concerns the gene VEGFA and neoplasm.