To determine the sensitivity of colon carcinomas to TRAIL-induced apoptosis, Colo205 and HCT15 cell lines were treated with increasing concentrations of rhTRAIL or DR5-selective TRAIL variant, D269H/E195R for 3 h (Figure 1A) (van der Sloot et al, 2006). The gene discussed is TNFSF10; the disease is colon carcinoma.