Furthermore, the growth inhibition of 10 MOI Ad-CMV-E1a-Apoptin or Ad-hTERT-E1a-Apoptin infected cells were similar to that of 100 MOI ofAd-CMV-E1a or Ad-hTERT-E1a, indicating that the adenoviruses with the dual cancer-specific genes were more effective than the normal replication-incompetent adenoviruses in inhibiting cell growth. The gene discussed is DHTKD1; the disease is cancer.