DHTKD1 and melanoma: In the melanoma cell lines (A375 and B16), infection with Ad-hTERT-E1a-Apoptin, Ad-CMV-E1a-Apoptin, Ad-hTERT-Apoptin and Ad-CMV-Apoptin resulted in significant production of Apoptin proteins (15 kDa), whereas no Apoptin protein was detected after Ad-hTERT-E1a, Ad-CMV-E1a or Ad-mock infection (Figure 1B and 1C).