Six multiple interacting TFs were found to have common functions between immune systems and cancer tissues, including CEBPGAMMA:NKX25:PLZF, CEBPGAMMA:PAX4:PLZF, CP2:NFY:PAX4, FOXJ2:PAX4:POU3F2, CEBPGAMMA:PAX4:PLZF, and FOXJ2:HNF3:PAX4. This evidence concerns the gene ZBTB16 and cancer.