F2 and anemia (phenotype): The most frequently observed alterations in laboratory parameters in these patients included leukocytosis, anemia, thrombocytopenia, elevated hepatic enzymes [alanine aminotransferase (ALT) and asparate aminotransferase (AST)] in the range of 100 to 200 IU/dl, elevated serum bilirubin levels in the range of 2–8 mg/dl, thrombocytopenia, increased prothrombin time, and D-dimer positivity (Table 5).