In this report, B. cenocepacia from the ET-12 lineage and clinical isolates were shown to exhibit virulence features potentially implicated in bacterial dissemination into the circulation and acute pulmonary decline detected in susceptible CF patients: cytotoxicity to airway epithelial cells, capability of enhancing the release of TF-bearing microparticles from infected cells and generating a TF-dependent procoagulant environment. Here, TF is linked to cystic fibrosis.